Linked Life Data

10332853

Source:http://linkedlifedata.com/resource/pubmed/id/10332853

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-6-29
pubmed:abstractText
A series of new diethylene triamine pentaacetic acid (DTPA)-bisamide chelates containing bulky alkyl and aryl side chains have been prepared and characterized. Nuclear magnetic relaxation dispersion profiles were measured for the neutral gadolinium [Gd(III)] DTPA-bisamide complexes in water solution, and their chemical exchange times (tau(m)) were found to be in the range of 1.4 to 4.9 micros. Significant enhancements of solvent proton relaxation rates were observed between 10 and 50 MHz for one of the complexes of the series [Gd(III)-DTPA-bis-2-ethylhexylamide] in human serum albumin (HSA) solution, indicating the formation of a paramagnetic macromolecular adduct. The binding association constant K(A) of the complex and the albumin 5.7 x 10(3) M(-1) was obtained, and the relaxivity of the fully bound adduct was determined to be 13.8 mM(-1) s(-1) at 20 MHz and 25 degrees C. The high value of K(A) makes the above derivative a good potential blood pool contrast agent at the physiological HSA concentration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0740-3194
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
767-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Non-ionic bulky Gd(III) DTPA-bisamide complexes as potential contrast agents for magnetic resonance imaging.
pubmed:affiliation
School of Biological and Applied Sciences, University of North London, United Kingdom. a.bligh@unl.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't