Source:http://linkedlifedata.com/resource/pubmed/id/10332833
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1999-8-3
|
| pubmed:abstractText |
Although Mycobacterium simiae was identified and classified more than three decades ago, only a few cases are mentioned in the current literature. After experimental simian immunodeficiency virus infection, a 9-year-old female rhesus monkey (Macaca mulatta) developed progressive immunosuppression and gastrointestinal disease very similar to the clinical and pathomorphologic features of Johne's disease, which is caused by M. paratuberculosis. Acid-fast-positive bacteria reacted immunohistochemically with antibodies against M. paratuberculosis and M. bovis but were not useful for differentiation because of a high degree of cross-reactivity. In contrast to immunohistochemistry and histopathology, biochemical methods and cycle sequencing analysis of the 16S ribosomal RNA identified M. simiae as the disease-causing pathogen. This case demonstrates the importance of molecular biological methods for the diagnosis of M. simiae infection in monkeys.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0300-9858
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
249-52
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| pubmed:dateRevised |
2005-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10332833-Animals,
pubmed-meshheading:10332833-Antibodies, Bacterial,
pubmed-meshheading:10332833-Base Sequence,
pubmed-meshheading:10332833-DNA Primers,
pubmed-meshheading:10332833-Fatal Outcome,
pubmed-meshheading:10332833-Female,
pubmed-meshheading:10332833-Gastrointestinal Diseases,
pubmed-meshheading:10332833-Immunocompromised Host,
pubmed-meshheading:10332833-Immunohistochemistry,
pubmed-meshheading:10332833-Intestinal Mucosa,
pubmed-meshheading:10332833-Intestine, Small,
pubmed-meshheading:10332833-Macaca mulatta,
pubmed-meshheading:10332833-Molecular Sequence Data,
pubmed-meshheading:10332833-Mycobacterium,
pubmed-meshheading:10332833-Mycobacterium Infections,
pubmed-meshheading:10332833-Polymerase Chain Reaction,
pubmed-meshheading:10332833-RNA, Ribosomal, 16S,
pubmed-meshheading:10332833-Sequence Analysis, DNA,
pubmed-meshheading:10332833-Sequence Homology, Nucleic Acid,
pubmed-meshheading:10332833-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10332833-Simian immunodeficiency virus
|
| pubmed:year |
1999
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| pubmed:articleTitle |
A case of intestinal Mycobacterium simiae infection in an SIV-infected immunosuppressed rhesus monkey.
|
| pubmed:affiliation |
Abteilung Tiermedizin und Primatenhaltung, Deutsches Primatenzentrum, Göttingen, Germany. adidier@www.dpz.gwdg.de
|
| pubmed:publicationType |
Journal Article,
Case Reports
|