Linked Life Data

1033064

Source:http://linkedlifedata.com/resource/pubmed/id/1033064

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1977-1-29
pubmed:abstractText
The mitogenic activity of soybean agglutinin was found to depend on the presence of lectin aggregates formed in lectin preparations stored in the lyophilized state. Such soybean agglutinin preparations gave maximal stimulation of untreated pig lymph node cells and neuraminidase-treated mouse spleen cells at relatively high concentrations, ranging from 100 to 2000 mug/ml. After separation into unaggregated (divalent) and polymeric (tetra-and multivalent) fractions, it was found that the unaggregated lectin did not stimulate the cells, while the tetravalent and multivalent fractions were active and gave maximal stimulation at a concentration of 10 mug/ml. These results suggest that soybean agglutinin must have at least four sugar binding sites in order to be able to stimulate lymphocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
The requirement for tetravalency of soybean agglutinin for induction of mitogenic stimulation of lymphocytes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.