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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1999-8-3
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|
pubmed:abstractText |
A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Apr
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|
pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
19
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|
pubmed:volume |
9
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1171-4
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10328307-Animals,
pubmed-meshheading:10328307-Cyclooxygenase 2,
pubmed-meshheading:10328307-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:10328307-Cyclooxygenase Inhibitors,
pubmed-meshheading:10328307-Humans,
pubmed-meshheading:10328307-Isoenzymes,
pubmed-meshheading:10328307-Membrane Proteins,
pubmed-meshheading:10328307-Models, Chemical,
pubmed-meshheading:10328307-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:10328307-Rats,
pubmed-meshheading:10328307-Sulfonamides,
pubmed-meshheading:10328307-Thiazoles
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|
pubmed:year |
1999
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|
pubmed:articleTitle |
Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors.
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pubmed:affiliation |
G.D. Searle-Monsanto, St. Louis, MO 63198, USA.
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pubmed:publicationType |
Journal Article
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