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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-6-4
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pubmed:abstractText |
The c-Myb transcription factor is important for fetal hematopoiesis and has been proposed to mediate later stages of lymphocyte development. Using homozygous null c-Myb/Rag1 chimeric mice, we have determined that c-Myb plays an important role in the differentiation of macrophages and lymphocytes from precursor stem cells. We also determine that deletion of c-Myb leads to a complete block in early T cell development just before the oligopotent thymocyte matures into the definitive T cell precursor. These data indicate that c-Myb plays an important role at multiple stages of hematopoiesis and is required at an early stage of T cell development.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-1334460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-1347906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-1683894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-1709592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-2405253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-2461588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-2493727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-2508090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-2577875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-2785564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-2832742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-3194397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-398327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-7484464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-7730626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-7903854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-7913950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-7926766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8011294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8171333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8264615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8293461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8385609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8387091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8398978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8474446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8506294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8551234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8710361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8717506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8945476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-8946914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-9011176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-9490676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-9819403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10323859-9989493
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1073-8
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pubmed:dateRevised |
2010-6-4
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pubmed:meshHeading |
pubmed-meshheading:10323859-Animals,
pubmed-meshheading:10323859-Antigens, CD44,
pubmed-meshheading:10323859-Cell Differentiation,
pubmed-meshheading:10323859-Genes, RAG-1,
pubmed-meshheading:10323859-Hematopoiesis,
pubmed-meshheading:10323859-Hematopoietic Stem Cells,
pubmed-meshheading:10323859-Macrophages,
pubmed-meshheading:10323859-Mice,
pubmed-meshheading:10323859-Mice, Knockout,
pubmed-meshheading:10323859-Oncogenes,
pubmed-meshheading:10323859-Receptors, Interleukin-2,
pubmed-meshheading:10323859-T-Lymphocytes
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pubmed:year |
1999
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pubmed:articleTitle |
c-Myb is essential for early T cell development.
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pubmed:affiliation |
Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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