Source:http://linkedlifedata.com/resource/pubmed/id/10323776
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
1999-6-7
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| pubmed:abstractText |
Plasma lipoprotein(a) [Lp(a)] levels are largely genetically determined by sequences linked to the gene encoding apolipoprotein(a) [apo(a)], the distinct protein component of Lp(a). Apo(a) is highly polymorphic in length due to variation in the numbers of a sequence encoding the apo(a) kringle 4 domain, and plasma levels of Lp(a) are inversely correlated with apo(a) size. In 2 racially homogeneous Bantu populations from Tanzania differing in their dietary habits, we found that median plasma levels of Lp(a) were 48% lower in those living on a fish diet than in those living on a vegetarian diet. Considering the relationship between apo(a) size and Lp(a) plasma concentration, we have extensively evaluated apo(a) isoform distribution in the 2 populations to determine the impact of apo(a) size in the determination of Lp(a) values. The majority of individuals (82% of the fishermen and 80% of the vegetarians) had 2 expressed apo(a) alleles. Additionally, the fishermen had a high frequency of large apo(a) isoforms, whereas a higher frequency of small isoforms was found in the vegetarians. When subjects from the 2 groups were matched for apo(a) phenotype, the median Lp(a) value was 40% lower in Bantus on the fish diet than in those on the vegetarian diet. A significant inverse relationship was also found between plasma n-3 polyunsaturated fatty acids and Lp(a) levels (r=-0.24, P=0.01). The results of this study are consistent with the concept that a diet rich in n-3 polyunsaturated fatty acids, and not genetic differences, is responsible for the lower plasma levels of Lp(a) in the fish-eating Bantus and strongly suggest that a sustained fish-based diet is able to lower plasma levels of Lp(a).
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins A,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-3,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoprotein(a),
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1079-5642
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
19
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1250-6
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10323776-Adult,
pubmed-meshheading:10323776-African Continental Ancestry Group,
pubmed-meshheading:10323776-Animals,
pubmed-meshheading:10323776-Apolipoproteins A,
pubmed-meshheading:10323776-Arachidonic Acids,
pubmed-meshheading:10323776-Cholesterol,
pubmed-meshheading:10323776-Diet, Vegetarian,
pubmed-meshheading:10323776-Ethnic Groups,
pubmed-meshheading:10323776-Fatty Acids, Omega-3,
pubmed-meshheading:10323776-Female,
pubmed-meshheading:10323776-Fishes,
pubmed-meshheading:10323776-Food Habits,
pubmed-meshheading:10323776-Humans,
pubmed-meshheading:10323776-Lipoprotein(a),
pubmed-meshheading:10323776-Male,
pubmed-meshheading:10323776-Meat,
pubmed-meshheading:10323776-Occupations,
pubmed-meshheading:10323776-Phenotype,
pubmed-meshheading:10323776-Protein Isoforms,
pubmed-meshheading:10323776-Tanzania,
pubmed-meshheading:10323776-Triglycerides
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| pubmed:year |
1999
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| pubmed:articleTitle |
Fish intake, independent of apo(a) size, accounts for lower plasma lipoprotein(a) levels in Bantu fishermen of Tanzania: The Lugalawa Study.
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| pubmed:affiliation |
Department of Medicine, University of Washington, Seattle, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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