Linked Life Data

1032220

Source:http://linkedlifedata.com/resource/pubmed/id/1032220

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1978-3-10
pubmed:abstractText
Adenine nucleotides and adenosine are known to be of importance in the regulation of coronary function. This made a study of the effect of neurohormone "C" on the metabolism of adenine nucleotides and adenosine interesting in as much as neurohormone "C" dilates coronary vessels and has a direct metabolic effect on cardiac muscle. The results obtained have shown that incubation of cardiac muscle homogenates with labelled ATP increased the content of adenosine through raising 5'-AMP nucleotidase activity and inhibiting adenosine deaminase activity. In homogenates and slices of brain tissue the content of adenosine is, on the contrary, reduced. Opposite changes are observed in the content of AMP. The increase of adenosine in the heart by the increase of 5'-AMP nucleotidase activity and decrease of adenosine deaminase activity is probably, not the main factor of the coronarodilatatory effect of neurohormone "C". The reverse phenomena is noticed in brain, the functional significance of which must be studied. However, the role of adenosine in the mechanism of action of neurohormone "C" will become clear after in vivo experiments which are in progress.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0507-2972
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-207
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
[Effect of neurohormone "C" on adenine nucleotide and adenosine metabolism in rat heart and brain].
pubmed:publicationType
Journal Article, English Abstract