Linked Life Data

10322128

Source:http://linkedlifedata.com/resource/pubmed/id/10322128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-6-22
pubmed:abstractText
The secosteroid 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) acts through the vitamin D receptor (VDR) to elicit many activities that make it a promising drug candidate for the treatment of a number of diseases, including cancer and psoriasis. Clinical use of 1,25(OH)2D3 has been limited by hypercalcemia elicited by pharmacologically effective doses. We hypothesized that structurally distinct, nonsecosteroidal mimics of 1,25(OH)2D3 might have different activity profiles from vitamin D analogs, and set out to discover such compounds by screening small-molecule libraries.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1074-5521
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-75
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10322128-Animals, pubmed-meshheading:10322128-Antineoplastic Agents, pubmed-meshheading:10322128-Biological Transport, pubmed-meshheading:10322128-Breast Neoplasms, pubmed-meshheading:10322128-Calcitriol, pubmed-meshheading:10322128-Calcium, pubmed-meshheading:10322128-Calcium Channel Agonists, pubmed-meshheading:10322128-Cell Differentiation, pubmed-meshheading:10322128-Cell Division, pubmed-meshheading:10322128-Female, pubmed-meshheading:10322128-HL-60 Cells, pubmed-meshheading:10322128-Humans, pubmed-meshheading:10322128-Keratinocytes, pubmed-meshheading:10322128-Ketones, pubmed-meshheading:10322128-Macrophages, pubmed-meshheading:10322128-Male, pubmed-meshheading:10322128-Mice, pubmed-meshheading:10322128-Molecular Mimicry, pubmed-meshheading:10322128-Phenyl Ethers, pubmed-meshheading:10322128-Prostatic Neoplasms, pubmed-meshheading:10322128-Rats, pubmed-meshheading:10322128-Receptors, Calcitriol, pubmed-meshheading:10322128-Transcriptional Activation, pubmed-meshheading:10322128-Vitamin D, pubmed-meshheading:10322128-Vitamin D-Binding Protein
pubmed:year
1999
pubmed:articleTitle
Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3.
pubmed:affiliation
Department of Medicinal Chemistry, Ligand Pharmaceuticals, Inc. 10255 Science Center Drive, San Diego, CA 92121, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't