Source:http://linkedlifedata.com/resource/pubmed/id/10322126
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1999-6-22
|
| pubmed:abstractText |
The substrate sites of enzymes are attractive targets for structure-based inhibitor design. Two difficulties hinder efforts to discover and elaborate new (nonsubstrate-like) inhibitors for these sites. First, novel inhibitors often bind at nonsubstrate sites. Second, a novel scaffold introduces chemistry that is frequently unfamiliar, making synthetic elaboration challenging.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1074-5521
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
319-31
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10322126-Catalytic Domain,
pubmed-meshheading:10322126-Drug Design,
pubmed-meshheading:10322126-Enzyme Inhibitors,
pubmed-meshheading:10322126-Folic Acid Antagonists,
pubmed-meshheading:10322126-Lactobacillus casei,
pubmed-meshheading:10322126-Models, Molecular,
pubmed-meshheading:10322126-Structure-Activity Relationship,
pubmed-meshheading:10322126-Thymidylate Synthase
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase.
|
| pubmed:affiliation |
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, IL 60611-3008, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|