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pubmed-article:10321986pubmed:abstractTextActive immunisation with rubella vaccine has not been commonly associated with neurological complications. We report the case of a 23-year-old woman who developed a mild, distal demyelinating neuropathy after immunisation with the live attenuated RA 27/3 rubella strain. Post-immunisation immunologic studies carried over 24 months showed the presence of antibodies to the RV proteins, particularly to the capsid antigen, and to the myelin basic protein (MBP). A similarity between a C antigen motif and a sequence of the MBP was found by computer analysis. The cross-reactivity was confirmed by immunising mice with a synthetic peptide derived from the MBP, which developed a strong humoral response to RV and MBP. This finding raises the possibility that a virus-induced immune response could lead to an autoaggressive reaction responsible for demyelination.lld:pubmed
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pubmed-article:10321986pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:10321986pubmed:articleTitlePeripheral neuropathy associated with anti-myelin basic protein antibodies in a woman vaccinated with rubella virus vaccine.lld:pubmed
pubmed-article:10321986pubmed:affiliationDipartimento di Biologia Molecolare, Università di Siena, Italia.lld:pubmed
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