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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
2
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|
pubmed:dateCreated |
1999-7-1
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|
pubmed:abstractText |
Active immunisation with rubella vaccine has not been commonly associated with neurological complications. We report the case of a 23-year-old woman who developed a mild, distal demyelinating neuropathy after immunisation with the live attenuated RA 27/3 rubella strain. Post-immunisation immunologic studies carried over 24 months showed the presence of antibodies to the RV proteins, particularly to the capsid antigen, and to the myelin basic protein (MBP). A similarity between a C antigen motif and a sequence of the MBP was found by computer analysis. The cross-reactivity was confirmed by immunising mice with a synthetic peptide derived from the MBP, which developed a strong humoral response to RV and MBP. This finding raises the possibility that a virus-induced immune response could lead to an autoaggressive reaction responsible for demyelination.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1355-0284
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
5
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
209-14
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|
pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10321986-Adult,
pubmed-meshheading:10321986-Animals,
pubmed-meshheading:10321986-Antibodies,
pubmed-meshheading:10321986-Antibodies, Viral,
pubmed-meshheading:10321986-Antibody Specificity,
pubmed-meshheading:10321986-Antigens, Viral,
pubmed-meshheading:10321986-Blotting, Western,
pubmed-meshheading:10321986-Cross Reactions,
pubmed-meshheading:10321986-Demyelinating Diseases,
pubmed-meshheading:10321986-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10321986-Female,
pubmed-meshheading:10321986-Humans,
pubmed-meshheading:10321986-Mice,
pubmed-meshheading:10321986-Mice, Inbred BALB C,
pubmed-meshheading:10321986-Myelin Basic Proteins,
pubmed-meshheading:10321986-Peptides,
pubmed-meshheading:10321986-Rubella Vaccine,
pubmed-meshheading:10321986-Rubella virus
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|
pubmed:year |
1999
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|
pubmed:articleTitle |
Peripheral neuropathy associated with anti-myelin basic protein antibodies in a woman vaccinated with rubella virus vaccine.
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|
pubmed:affiliation |
Dipartimento di Biologia Molecolare, Università di Siena, Italia.
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pubmed:publicationType |
Journal Article,
Case Reports
|
