|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1999-5-20
|
|
pubmed:abstractText |
Dolastatin 10 is a natural cytotoxic peptide which acts through the inhibition of microtubule assembly. Studies have suggested that such agents can induce apoptosis in association with bcl-2 phosphorylation. Since bcl-2 overexpression is common in small-cell lung cancer (SCLC), we evaluated the activity of dolastatin 10 in SCLC cell lines and xenografts.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0344-5704
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
43
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
507-15
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10321512-Animals,
pubmed-meshheading:10321512-Antineoplastic Agents,
pubmed-meshheading:10321512-Apoptosis,
pubmed-meshheading:10321512-Carcinoma, Small Cell,
pubmed-meshheading:10321512-Depsipeptides,
pubmed-meshheading:10321512-Female,
pubmed-meshheading:10321512-Humans,
pubmed-meshheading:10321512-Lung Neoplasms,
pubmed-meshheading:10321512-Mice,
pubmed-meshheading:10321512-Mice, SCID,
pubmed-meshheading:10321512-Neoplasm Transplantation,
pubmed-meshheading:10321512-Oligopeptides,
pubmed-meshheading:10321512-Phosphorylation,
pubmed-meshheading:10321512-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10321512-Transplantation, Heterologous,
pubmed-meshheading:10321512-Tumor Cells, Cultured
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: induction of apoptosis and bcl-2 modification.
|
|
pubmed:affiliation |
Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA. kalemker@karmanos.org
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
