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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1999-6-24
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pubmed:abstractText |
One-pot syntheses provided a series of triazole- and pentafluorophenyloxy-substituted pyrimidine nucleosides. Most of the compounds in the series displayed anti-HIV activities but none as potent as AZT 2. 1-(beta-D-Erythro-pentofuranosyl)-4-pentafluorophenyloxy-2(1H)-pyr imidinone 14 was the most potent and the most selective compound in the series with EC50 = 1.6 microM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0014-827X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10321033-Anti-HIV Agents,
pubmed-meshheading:10321033-Cell Line,
pubmed-meshheading:10321033-Cell Survival,
pubmed-meshheading:10321033-HIV-1,
pubmed-meshheading:10321033-Humans,
pubmed-meshheading:10321033-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10321033-Pyrimidine Nucleosides,
pubmed-meshheading:10321033-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:10321033-Viral Plaque Assay
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pubmed:articleTitle |
Synthesis and anti-HIV activity of C4-modified pyrimidine nucleosides.
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pubmed:affiliation |
Pharmaceutical Sciences Research Institute, Aston University, Birmingham, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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