Source:http://linkedlifedata.com/resource/pubmed/id/10320798
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1999-7-7
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pubmed:abstractText |
Mu and delta opioid receptors were labeled in enkephalin knockout mice by quantitative autoradiography. Discrete, large increases (100-300%) were found in limbic forebrain structures for mu binding and striatum and pallidum for delta binding. The up-regulation of opioid receptors may reflect a form of 'denervation supersensitivity. ' The receptor up-regulation in limbic areas is consistent with the increased emotional and aggressive behaviors observed in the enkephalin knockout mice.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0169-328X
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 1999 Elsevier Science B.V.
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10320798-Animals,
pubmed-meshheading:10320798-Autoradiography,
pubmed-meshheading:10320798-Brain,
pubmed-meshheading:10320798-Enkephalins,
pubmed-meshheading:10320798-Male,
pubmed-meshheading:10320798-Mice,
pubmed-meshheading:10320798-Mice, Knockout,
pubmed-meshheading:10320798-Receptors, Opioid, delta,
pubmed-meshheading:10320798-Receptors, Opioid, mu,
pubmed-meshheading:10320798-Up-Regulation
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pubmed:year |
1999
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pubmed:articleTitle |
Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice.
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pubmed:affiliation |
Section on Functional Neuroanatomy, Intramural Research Program, NIMH, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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