Linked Life Data

10320778

Source:http://linkedlifedata.com/resource/pubmed/id/10320778

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1999-7-7
pubmed:abstractText
We examined the distribution of the high affinity neurotrophin receptors (trkA, trkB, and trkC) in the rat geniculate ganglion. Previous work had shown that during early (prenatal) development, trkB and its two ligands, BDNF and NT-4/5, were most important for survival of almost all neurons. Using nested polymerase chain reaction (PCR), we showed that trkA, trkB, and trkC transcripts were expressed, and the mRNAs for trkB and trkC were more abundant than that for trkA. We modified and improved the method for direct reverse transcription in situ PCR and localized trkB mRNA in approximately one third of the neurons in the ganglion. Immunohistochemical data confirmed that approximately the same fraction of neurons was immunoreactive with antibody vs. trkB, and an approximately equal fraction was immunoreactive with trkC antibody. These results are consistent with the notion that both BDNF/trkB and NT-3/trkC play important roles in maintenance of the geniculate ganglion neurons and possibly the peripheral taste system in the young postnatal rat.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0169-328X
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Elsevier Science B.V.
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-13
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Neurotrophin receptors in the geniculate ganglion.
pubmed:affiliation
Department of Neurobiology and Physiology, Northwestern University, 2153 North Campus Drive, Evanston, IL 60208-3520, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.