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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-6-8
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pubmed:abstractText |
The aim of this study was to investigate the use of [18F]fluoro-2-deoxy-D-glucose (FDG) and a small-animal PET scanner to assess early tumor response after photodynamic therapy (PDT) in mice. PDT consists of intravenous administration of a photosensitizer that accumulates preferentially in tumor tissue, followed by local illumination of the tumor with red light. Two different photosensitizers were used: Photofrin (PII), which has been approved for clinical use, and disulfonated aluminum phthalocyanine (AIPcS), which is a second-generation drug. These drugs have been shown to induce tumor necrosis through different action mechanisms, i.e., mainly initial vascular stasis (PII) or direct tumor cell kill (AIPcS). FDG PET was used to follow both perfusion and metabolic activity in the tumor tissue.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
876-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10319764-Aluminum,
pubmed-meshheading:10319764-Animals,
pubmed-meshheading:10319764-Antineoplastic Agents,
pubmed-meshheading:10319764-Dihematoporphyrin Ether,
pubmed-meshheading:10319764-Feasibility Studies,
pubmed-meshheading:10319764-Fluorodeoxyglucose F18,
pubmed-meshheading:10319764-Indoles,
pubmed-meshheading:10319764-Male,
pubmed-meshheading:10319764-Mammary Neoplasms, Experimental,
pubmed-meshheading:10319764-Mice,
pubmed-meshheading:10319764-Mice, Inbred BALB C,
pubmed-meshheading:10319764-Neoplasm Transplantation,
pubmed-meshheading:10319764-Organometallic Compounds,
pubmed-meshheading:10319764-Photochemotherapy,
pubmed-meshheading:10319764-Photosensitizing Agents,
pubmed-meshheading:10319764-Pilot Projects,
pubmed-meshheading:10319764-Radiopharmaceuticals,
pubmed-meshheading:10319764-Tomography, Emission-Computed
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pubmed:year |
1999
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|
pubmed:articleTitle |
High-resolution PET imaging for in vivo monitoring of tumor response after photodynamic therapy in mice.
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pubmed:affiliation |
Centre d'Imagerie Métabolique et Fonctionnelle, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine, Université de Sherbrooke, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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