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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1999-6-17
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pubmed:databankReference |
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pubmed:abstractText |
Norepinephrine inhibits omega-conotoxin GVIA-sensitive presynaptic Ca2+ channels in chick dorsal root ganglion neurons through two pathways, one mediated by Go and the other by Gi. These pathways desensitize at different rates. We have found that recombinant Galpha interacting protein (GAIP) and regulators of G protein signaling (RGS)4 selectively accelerate the rate of desensitization of Go- and Gi-mediated pathways, respectively. Blockade of endogenous RGS proteins using antibodies raised against Galpha interacting protein and RGS4 slows the rate of desensitization of these pathways in a selective manner. These results demonstrate that different RGS proteins may interact with Gi and Go selectively, giving rise to distinct time courses of transmitter-mediated effects.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mollusk Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RGS Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RGS4 protein,
http://linkedlifedata.com/resource/pubmed/chemical/omega-Conotoxin GVIA,
http://linkedlifedata.com/resource/pubmed/chemical/ras GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/regulator of G-protein signalling 19
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
274
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14490-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10318875-Amino Acid Sequence,
pubmed-meshheading:10318875-Animals,
pubmed-meshheading:10318875-Calcium Channel Blockers,
pubmed-meshheading:10318875-Calcium Channels,
pubmed-meshheading:10318875-Cells, Cultured,
pubmed-meshheading:10318875-Chick Embryo,
pubmed-meshheading:10318875-Electrophysiology,
pubmed-meshheading:10318875-GTP Phosphohydrolases,
pubmed-meshheading:10318875-GTP-Binding Proteins,
pubmed-meshheading:10318875-GTPase-Activating Proteins,
pubmed-meshheading:10318875-Molecular Sequence Data,
pubmed-meshheading:10318875-Mollusk Venoms,
pubmed-meshheading:10318875-Neurons,
pubmed-meshheading:10318875-Peptides,
pubmed-meshheading:10318875-Phosphoproteins,
pubmed-meshheading:10318875-Presynaptic Terminals,
pubmed-meshheading:10318875-Proteins,
pubmed-meshheading:10318875-RGS Proteins,
pubmed-meshheading:10318875-Signal Transduction,
pubmed-meshheading:10318875-omega-Conotoxin GVIA,
pubmed-meshheading:10318875-ras GTPase-Activating Proteins,
pubmed-meshheading:10318875-ras Proteins
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pubmed:year |
1999
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pubmed:articleTitle |
Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels.
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pubmed:affiliation |
Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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