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pubmed:abstractText |
The influence of a number of neuroleptics and antidepressants on the release of 3H-GABA from the synaptosomas of the cerebral cortex in rats was studied. Chlorpromazine, phthorphenazine, trifluperidol, imipramine, phthoracizine caused an intensified liberation of 3H-GABA from the synaptosomas. In this phenothiazine neuroleptics proved more active than did trifluperidol and antidepressants. New neuroleptics--azabuperon and carbidine and also diphenylhydantoin tended to restrict the liberation of the mediator from synaptosomas. The tranquilizer diazepam, gamma-oxybutyric acid and carbamazepine failed to have any significnat effect on this process. The described effects of thepsychotropic substances are due, apparently, to their direct influence on the synaptomal membrane.
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