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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
6
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pubmed:dateCreated |
1977-7-29
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pubmed:abstractText |
Thiaminase from bicuspid mollusc, after a single administration into mice (25 or 50 un, subcutaneously), caused a decrease in the activity of transketolase and alpha-ketoglutaric acid dehydrogenase in the animal tissues within 3 hrs. The maximal antivitaminous effect of thiaminase was manifested within 2-5 days and slightly decreased within 7 days (at a dose of 25 un). Amount of thiamin was decreased in mice liver tissue from 6.54+/-0.36 mcg/g to 4.84+/-0.23 mcg/g within the second day after the thiaminase administration. Transketolase and alpha-ketoglutarate dehydrogenase from liver and kidney were more sensitive to the antivitaminous effect of thiaminase. General condition of the animals was not altered by parenteral administration of thiaminase during a week. Thiaminase may be recommended for modelling of thiamin deficiency in animals maintained at conventional diets.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0042-8809
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
769-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1027249-Animals,
pubmed-meshheading:1027249-Hydrolases,
pubmed-meshheading:1027249-Injections, Subcutaneous,
pubmed-meshheading:1027249-Ketoglutarate Dehydrogenase Complex,
pubmed-meshheading:1027249-Ketoglutaric Acids,
pubmed-meshheading:1027249-Kidney,
pubmed-meshheading:1027249-Liver,
pubmed-meshheading:1027249-Mice,
pubmed-meshheading:1027249-Mollusca,
pubmed-meshheading:1027249-Muscles,
pubmed-meshheading:1027249-Myocardium,
pubmed-meshheading:1027249-Spleen,
pubmed-meshheading:1027249-Thiamine,
pubmed-meshheading:1027249-Time Factors,
pubmed-meshheading:1027249-Transketolase
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pubmed:articleTitle |
[Antivitamin activity of thiaminase from freshwater bicuspid molluscs after parenteral administration of the enzyme to albino mice].
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pubmed:publicationType |
Journal Article,
English Abstract
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