Source:http://linkedlifedata.com/resource/pubmed/id/10234736
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1999-6-28
|
| pubmed:abstractText |
A novel series of 3-(3-phenyl-isoxazol-5-yl) or 3-[(3-phenyl-isoxazol-5-yl)amino] substituted 4(3H)-quinazolinone derivatives was synthesized. The compounds were tested for their antineoplastic activity in vitro against Raji (human Burkitt limphoma). K-562 (human chronic myelogeneous leukemia) and U937 (human histiocytic limphoma) cell lines. The most active quinazolinones showed IC50 values in the range 16-30 microM.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0031-7144
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
54
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
251-4
|
| pubmed:dateRevised |
2007-1-29
|
| pubmed:meshHeading |
pubmed-meshheading:10234736-Antineoplastic Agents,
pubmed-meshheading:10234736-Drug Screening Assays, Antitumor,
pubmed-meshheading:10234736-Humans,
pubmed-meshheading:10234736-Inhibitory Concentration 50,
pubmed-meshheading:10234736-Isoxazoles,
pubmed-meshheading:10234736-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10234736-Quinazolines,
pubmed-meshheading:10234736-Spectrophotometry, Infrared,
pubmed-meshheading:10234736-Tumor Cells, Cultured
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Synthesis of new 3-(3-phenyl-isoxazol-5-yl) or 3-[(3-phenyl-isoxazol-5-yl)-amino] substituted 4(3H)-quinazolinone derivatives with antineoplastic activity.
|
| pubmed:affiliation |
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Italy.
|
| pubmed:publicationType |
Journal Article
|