Linked Life Data

10234572

Source:http://linkedlifedata.com/resource/pubmed/id/10234572

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10234572rdf:typepubmed:Citationlld:pubmed
pubmed-article:10234572lifeskim:mentionsumls-concept:C0043210lld:lifeskim
pubmed-article:10234572lifeskim:mentionsumls-concept:C0029456lld:lifeskim
pubmed-article:10234572lifeskim:mentionsumls-concept:C0538161lld:lifeskim
pubmed-article:10234572lifeskim:mentionsumls-concept:C0683149lld:lifeskim
pubmed-article:10234572lifeskim:mentionsumls-concept:C0232970lld:lifeskim
pubmed-article:10234572lifeskim:mentionsumls-concept:C0205217lld:lifeskim
pubmed-article:10234572lifeskim:mentionsumls-concept:C0175630lld:lifeskim
pubmed-article:10234572lifeskim:mentionsumls-concept:C0205470lld:lifeskim
pubmed-article:10234572lifeskim:mentionsumls-concept:C1880022lld:lifeskim
pubmed-article:10234572pubmed:issue4lld:pubmed
pubmed-article:10234572pubmed:dateCreated1999-7-6lld:pubmed
pubmed-article:10234572pubmed:abstractTextOsteoprotegerin (OPG)/osteoclastogenesis inhibitory factor (OCIF) is a soluble member of the tumor necrosis factor receptor family of proteins and plays an important role in the negative regulation of osteoclastic bone resorption. Whether OPG/OCIF circulates in human blood and how its level changes under pathological conditions is not known. To address these issues, a panel of monoclonal antibodies was generated against recombinant OPG/OCIF and screened for reactivity with solid-phase monomeric and homodimeric forms of the recombinant protein. Antibodies that showed high affinity for both forms of OPG/OCIF and those that selectively recognized the homodimer were identified, enabling development of two types of sensitive enzyme-linked immunosorbent assay (ELISA): one that detects both forms of OPG/OCIF equally and one specific for the homodimer. Characterization of circulating OPG/OCIF with these ELISAs revealed that the protein exists in human serum mainly in the monomeric form. The serum concentration of OPG/OCIF increased with age in both healthy Japanese men and women, and was significantly higher in postmenopausal women with osteoporosis than in age-matched controls. Within the osteoporotic group, serum OPG/OCIF concentrations were higher in patients with low bone mass. Serum OPG/OCIF concentrations were also significantly increased in those postmenopausal women with a high rate of bone turnover, as determined by increased serum bone-specific alkaline phosphatase and urinary excretion of pyridinoline and deoxypyridinoline. The results suggested that circulating OPG/OCIF levels are regulated by an age-related factor(s) and that the increased serum concentration may reflect a compensative response to enhanced osteoclastic bone resorption and the resultant bone loss rather than a cause of osteoporosis.lld:pubmed
pubmed-article:10234572pubmed:languageenglld:pubmed
pubmed-article:10234572pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10234572pubmed:citationSubsetIMlld:pubmed
pubmed-article:10234572pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10234572pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10234572pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10234572pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10234572pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10234572pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10234572pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10234572pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10234572pubmed:statusMEDLINElld:pubmed
pubmed-article:10234572pubmed:monthAprlld:pubmed
pubmed-article:10234572pubmed:issn0884-0431lld:pubmed
pubmed-article:10234572pubmed:authorpubmed-author:YamadaYYlld:pubmed
pubmed-article:10234572pubmed:authorpubmed-author:IkedaKKlld:pubmed
pubmed-article:10234572pubmed:authorpubmed-author:KobayashiFFlld:pubmed
pubmed-article:10234572pubmed:authorpubmed-author:GotoMMlld:pubmed
pubmed-article:10234572pubmed:authorpubmed-author:YangCClld:pubmed
pubmed-article:10234572pubmed:authorpubmed-author:TsudaEElld:pubmed
pubmed-article:10234572pubmed:authorpubmed-author:HaradaAAlld:pubmed
pubmed-article:10234572pubmed:authorpubmed-author:HigashioKKlld:pubmed
pubmed-article:10234572pubmed:authorpubmed-author:WashidaNNlld:pubmed
pubmed-article:10234572pubmed:issnTypePrintlld:pubmed
pubmed-article:10234572pubmed:volume14lld:pubmed
pubmed-article:10234572pubmed:ownerNLMlld:pubmed
pubmed-article:10234572pubmed:authorsCompleteYlld:pubmed
pubmed-article:10234572pubmed:pagination518-27lld:pubmed
pubmed-article:10234572pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:meshHeadingpubmed-meshheading:10234572...lld:pubmed
pubmed-article:10234572pubmed:year1999lld:pubmed
pubmed-article:10234572pubmed:articleTitleImmunological characterization of circulating osteoprotegerin/osteoclastogenesis inhibitory factor: increased serum concentrations in postmenopausal women with osteoporosis.lld:pubmed
pubmed-article:10234572pubmed:affiliationResearch Institute of Life Science, Snow Brand Milk Products Co., Ltd, Tochigi, Japan.lld:pubmed
pubmed-article:10234572pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10234572pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10234572lld:pubmed