Linked Life Data

10232692

Source:http://linkedlifedata.com/resource/pubmed/id/10232692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-6-22
pubmed:abstractText
This study investigates the basal and insulin-stimulated glucose metabolism, substrate utilization, and protein turnover in eight patients maintained on continuous ambulatory peritoneal dialysis (CAPD) (mean age 39+/-5 yr, body mass index [BMI] 108+/-6) and 14 control subjects (mean age 33+/-4 yr, BMI 103+/-3). Euglycemic insulin clamp studies (180 min) were performed in combination with continuous indirect calorimetry and 1-14C leucine infusion (study I). Postabsorptive glucose oxidation was higher (1.75+/-0.18 versus 1.42+/-0.14 mg/kg per min) and lipid oxidation was lower (0.43+/-0.09 versus 0.61+/-0.12 mg/kg per min) in CAPD patients than in control subjects (P<0.05 versus control subjects). During the last 60 min of euglycemic hyperinsulinemia, the total rate of glucose metabolism was similar in CAPD and control subjects (6.33+/-0.51 versus 6.54+/-0.62 mg/kg per min). Both insulin-stimulated glucose oxidation (2.53+/-0.27 versus 2.64+/-0.37 mg/kg per min) and glucose storage (3.70+/-0.48 versus 3.90+/-0.58 mg/kg per min) were similar in CAPD and control subjects. Basal leucine flux (an index of endogenous proteolysis) was significantly lower in CAPD patients than in control subjects (1.21+/-0.15 versus 1.65+/-0.07 micromol/kg per min). Leucine oxidation (0.13+/-0.02 versus 0.26+/-0.02 micromol/kg per min) and nonoxidative leucine disposal (an index of protein synthesis) (1.09+/-0.16 versus 1.35+/-0.05 micromol/kg per min) were also reduced in CAPD compared with control subjects (P<0.01 versus control subjects). In response to insulin (study I), endogenous leucine flux decreased to 0.83+/-0.08 and 1.05+/-0.05 micromol/kg per min in CAPD and control subjects, respectively (all P<0.01 versus basal). Leucine oxidation declined to 0.06+/-0.01 and to 0.19+/-0.02 micromol/kg per min in CAPD and control subjects, respectively (P<0.01 versus basal). A second insulin clamp was performed in combination with an intravenous amino acid infusion (study II). During insulin plus amino acid administration, nonoxidative leucine disposal rose to 1.23+/-0.17 and 1.42+/-0.09 micromol/kg per min in CAPD and control subjects, respectively (both P<0.05 versus basal, P = NS versus control subjects), and leucine balance, an index of the net amino acid flux into protein, become positive in both groups (0.30+/-0.05 versus 0.40+/-0.07 micromol/kg per min in CAPD and control subjects, respectively) (both P<0.01 versus basal, P = NS versus control subjects). In summary, in CAPD patients: (1) basal glucose oxidation is increased; (2) basal lipid oxidation is decreased; (3) insulin-mediated glucose oxidation and storage are normal; (4) basal leucine flux is reduced; (5) the antiproteolitic action of insulin is normal; and (6) the anabolic response to insulin plus amino acid administration is normal. Uremic patients maintained on CAPD treatment show a preferential utilization of glucose as postabsorptive energy substrate; however, their anabolic response to substrate administration and the sensitivity to insulin are normal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1046-6673
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1050-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:10232692-Adult, pubmed-meshheading:10232692-Amino Acids, pubmed-meshheading:10232692-Blood Glucose, pubmed-meshheading:10232692-Calorimetry, Indirect, pubmed-meshheading:10232692-Female, pubmed-meshheading:10232692-Glucose, pubmed-meshheading:10232692-Hormones, pubmed-meshheading:10232692-Humans, pubmed-meshheading:10232692-Insulin, pubmed-meshheading:10232692-Keto Acids, pubmed-meshheading:10232692-Kidney Failure, Chronic, pubmed-meshheading:10232692-Leucine, pubmed-meshheading:10232692-Lipid Metabolism, pubmed-meshheading:10232692-Male, pubmed-meshheading:10232692-Osmolar Concentration, pubmed-meshheading:10232692-Oxidation-Reduction, pubmed-meshheading:10232692-Peritoneal Dialysis, Continuous Ambulatory, pubmed-meshheading:10232692-Protein Biosynthesis, pubmed-meshheading:10232692-Reference Values
pubmed:year
1999
pubmed:articleTitle
Effects of insulin and amino acids on glucose and leucine metabolism in CAPD patients.
pubmed:affiliation
Istituto di Clinica Medica Generale e Terapia Medica, Universita' di Catania, Italy. pcastellino@ctonline.it
pubmed:publicationType
Journal Article, Clinical Trial