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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-7-7
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pubmed:abstractText |
DNA supercoiling factor (SCF) was first identified in the silkworm as a protein capable of generating negative supercoils into a relaxed DNA in conjunction with eukaryotic topoisomerase II. Drosophila melanogaster SCF localizes to puffs on polytene chromosomes, implicating its role in gene expression. The factor is a Ca2+-binding protein with four EF-hand domains and possesses a tetrapeptide sequence HDEF at its C-terminus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1356-9597
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10231391-Calcium,
pubmed-meshheading:10231391-Calcium-Binding Proteins,
pubmed-meshheading:10231391-DNA, Superhelical,
pubmed-meshheading:10231391-DNA Topoisomerases, Type II,
pubmed-meshheading:10231391-Dose-Response Relationship, Drug,
pubmed-meshheading:10231391-Drosophila Proteins,
pubmed-meshheading:10231391-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:10231391-Models, Biological,
pubmed-meshheading:10231391-Models, Genetic,
pubmed-meshheading:10231391-Mutagenesis,
pubmed-meshheading:10231391-Nuclear Proteins,
pubmed-meshheading:10231391-Sequence Analysis, DNA,
pubmed-meshheading:10231391-Structure-Activity Relationship
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pubmed:year |
1999
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pubmed:articleTitle |
Functional dissection of DNA supercoiling factor: EF-hand domains and C-terminal HDEF motif are essential for its activity.
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pubmed:affiliation |
Department of Developmental Genetics, National Institute of Genetics, Mishima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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