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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-5-26
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pubmed:abstractText |
Growing evidence indicates that the immune system and the hypothalamic-pituitary-adrenal system are linked by several mechanisms, for example intracellular glucocorticoid receptors (hGR). Glucocorticoids are the standard treatment of acute attacks of inflammatory bowel disease (IBD). Binding of glucocorticoids to hGR down-regulates the transcription of inflammatory genes that can propagate IBD.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-2972
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
330-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10231345-Binding, Competitive,
pubmed-meshheading:10231345-Cell Fractionation,
pubmed-meshheading:10231345-Colitis, Ulcerative,
pubmed-meshheading:10231345-Colon,
pubmed-meshheading:10231345-Crohn Disease,
pubmed-meshheading:10231345-Cytosol,
pubmed-meshheading:10231345-Dexamethasone,
pubmed-meshheading:10231345-Down-Regulation,
pubmed-meshheading:10231345-Glucocorticoids,
pubmed-meshheading:10231345-Humans,
pubmed-meshheading:10231345-Interleukin-6,
pubmed-meshheading:10231345-Intestinal Mucosa,
pubmed-meshheading:10231345-Leukocytes, Mononuclear,
pubmed-meshheading:10231345-Receptors, Glucocorticoid,
pubmed-meshheading:10231345-Tritium
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pubmed:year |
1999
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pubmed:articleTitle |
Glucocorticoid receptors are down-regulated in inflamed colonic mucosa but not in peripheral blood mononuclear cells from patients with inflammatory bowel disease.
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pubmed:affiliation |
Department of Internal Medicine I, University of Regensburg, Germany.
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pubmed:publicationType |
Journal Article
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