Linked Life Data

10229799

Source:http://linkedlifedata.com/resource/pubmed/id/10229799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1999-6-14
pubmed:abstractText
The binding kinetics of the TCR for its interacting ligand and the nature of the resulting signal transduction event determine the fate of a developing thymocyte. The intracellular tyrosine phosphatase SHP-1 is a potential regulator of the TCR signal transduction cascade and may affect thymocyte development. To assess the role of SHP-1 in thymocyte development, we generated T cell-transgenic mice that express a putative dominant negative form of SHP-1, in which a critical cysteine is mutated to serine (SHP-1 C453S). SHP-1 C453S mice that express the 3.L2 TCR transgene are increased in CD4 single positive cells in the thymus and are increased in cells that express the clonotypic TCR. These data suggest that the expression of SHP-1 C453S results in increased positive selection in 3.L2 TCR-transgenic mice and support a role for SHP-1 thymocyte development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5680-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:10229799-Animals, pubmed-meshheading:10229799-CD4-Positive T-Lymphocytes, pubmed-meshheading:10229799-Cysteine, pubmed-meshheading:10229799-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:10229799-Mice, pubmed-meshheading:10229799-Mice, Transgenic, pubmed-meshheading:10229799-Mutation, pubmed-meshheading:10229799-Protein Tyrosine Phosphatase, Non-Receptor Type 11, pubmed-meshheading:10229799-Protein Tyrosine Phosphatase, Non-Receptor Type 6, pubmed-meshheading:10229799-Protein Tyrosine Phosphatases, pubmed-meshheading:10229799-Receptors, Antigen, T-Cell, pubmed-meshheading:10229799-SH2 Domain-Containing Protein Tyrosine Phosphatases, pubmed-meshheading:10229799-Serine, pubmed-meshheading:10229799-Signal Transduction, pubmed-meshheading:10229799-Spleen, pubmed-meshheading:10229799-Thymus Gland, pubmed-meshheading:10229799-src Homology Domains
pubmed:year
1999
pubmed:articleTitle
Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection.
pubmed:affiliation
Howard Hughes Medical Institute, and Center for Immunology, Department of Pathology, Washington University, St. Louis, MO 63110, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't