Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1999-5-20
pubmed:abstractText
The CTL response was characterized during primary SIV/macaque (SIVmac) infection of rhesus monkeys to assess its role in containing early viral replication using both an epitope-specific functional and an MHC class I/peptide tetramer-binding assay. The rapid expansion of a single dominant viral epitope-specific CTL population to 1.3-8.3% of circulating CD8+ peripheral blood and 0. 3-1.3% of lymph node CD8+ T cells was observed, peaking at day 13 following infection. A subsequent decrease in number of these cells was then demonstrated. Interestingly, the percent of tetramer-binding CD8+ T cells detected in the lymph nodes of all evaluated animals was smaller than the percent detected in PBL. These epitope-specific CD8+ T cells expressed cell surface molecules associated with memory and activation. Early clearance of SIVmac occurred coincident with the emergence of the CTL response, suggesting that CTL may be important in containing virus replication. A higher percent of annexin V-binding cells was detected in the tetramer+ CD8+ T cells (range, from 33% to 75%) than in the remaining CD8+ T cells (range, from 3.3% to 15%) at the time of maximum CTL expansion in all evaluated animals. This finding indicates that the decrease of CTL occurred as a result of the death of these cells rather than their anatomic redistribution. These studies provide strong evidence for the importance of CTL in containing AIDS virus replication.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5127-33
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10227983-Animals, pubmed-meshheading:10227983-Annexin A5, pubmed-meshheading:10227983-CD8-Positive T-Lymphocytes, pubmed-meshheading:10227983-Cell Movement, pubmed-meshheading:10227983-Cytotoxicity, Immunologic, pubmed-meshheading:10227983-Histocompatibility Antigens Class I, pubmed-meshheading:10227983-Immunophenotyping, pubmed-meshheading:10227983-Lymph Nodes, pubmed-meshheading:10227983-Lymphocyte Count, pubmed-meshheading:10227983-Macaca mulatta, pubmed-meshheading:10227983-Major Histocompatibility Complex, pubmed-meshheading:10227983-Protein Binding, pubmed-meshheading:10227983-Simian Acquired Immunodeficiency Syndrome, pubmed-meshheading:10227983-Simian immunodeficiency virus, pubmed-meshheading:10227983-T-Lymphocytes, Cytotoxic, pubmed-meshheading:10227983-Virus Replication
pubmed:year
1999
pubmed:articleTitle
Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys.
pubmed:affiliation
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. mkuroda@bidmc.harvard.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.