| pubmed-article:10227982 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10227982 | lifeskim:mentions | umls-concept:C0699040 | lld:lifeskim |
| pubmed-article:10227982 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:10227982 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:10227982 | lifeskim:mentions | umls-concept:C1155013 | lld:lifeskim |
| pubmed-article:10227982 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10227982 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10227982 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10227982 | lifeskim:mentions | umls-concept:C0766839 | lld:lifeskim |
| pubmed-article:10227982 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10227982 | pubmed:dateCreated | 1999-5-20 | lld:pubmed |
| pubmed-article:10227982 | pubmed:abstractText | Thymic shared Ag-2 (TSA-2) is a 28-kDa, glycophosphatidylinitosol-linked cell surface molecule expressed on various T cell and thymic stromal cell subsets. It is expressed on most CD3-CD4-CD8-, CD4+CD8+, and CD3highCD4-CD8+ thymocytes but is down-regulated on approximately 40% of CD3highCD4+CD8- thymocytes. Expression on peripheral TCR-alphabeta+ T cells is similar to that of CD3+ thymocytes, although a transient down-regulation occurs with cell activation. Consistent with the recent hypothesis that emigration from the thymus is an active process, recent thymic emigrants are primarily TSA-2-/low. TSA-2 expression reveals heterogeneity among subpopulations of CD3highCD4+CD8- thymocytes and TCR-gamma delta+ T cell previously regarded as homogenous. The functional importance of TSA-2 was illustrated by the severe block in T cell differentiation caused by adding purified anti-TSA-2 mAb to reconstituted fetal thymic organ culture. While each CD25/CD44-defined triple-negative subset was present, differentiation beyond the TN stage was essentially absent, and cell numbers of all subsets were significantly below those of control cultures. Cross-linking TSA-2 on thymocytes caused a significant Ca2+ influx but no increase in apoptosis, unless anti-TSA-2 was used in conjunction with suboptimal anti-CD3 mAb. Similar treatment of mature TSA-2+ T cells had no effect on cell survival or proliferation. This study reveals TSA-2 to be a functionally important molecule in T cell development and a novel indicator of heterogeneity among a variety of developing and mature T cell populations. | lld:pubmed |
| pubmed-article:10227982 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10227982 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227982 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10227982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10227982 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10227982 | pubmed:month | May | lld:pubmed |
| pubmed-article:10227982 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10227982 | pubmed:author | pubmed-author:BoydR LRL | lld:pubmed |
| pubmed-article:10227982 | pubmed:author | pubmed-author:FraserSS | lld:pubmed |
| pubmed-article:10227982 | pubmed:author | pubmed-author:ClassonB JBJ | lld:pubmed |
| pubmed-article:10227982 | pubmed:author | pubmed-author:MalinM AMA | lld:pubmed |
| pubmed-article:10227982 | pubmed:author | pubmed-author:DaveyG MGM | lld:pubmed |
| pubmed-article:10227982 | pubmed:author | pubmed-author:BerzinsS PSP | lld:pubmed |
| pubmed-article:10227982 | pubmed:author | pubmed-author:Randle-Barret... | lld:pubmed |
| pubmed-article:10227982 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10227982 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10227982 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:10227982 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10227982 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10227982 | pubmed:pagination | 5119-26 | lld:pubmed |
| pubmed-article:10227982 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10227982 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10227982 | pubmed:articleTitle | Thymic shared antigen-2: a novel cell surface marker associated with T cell differentiation and activation. | lld:pubmed |
| pubmed-article:10227982 | pubmed:affiliation | Department of Pathology and Immunology, Monash Medical School, Prahran, Australia. Stuart.Berzins@med.monash.edu.au | lld:pubmed |
| pubmed-article:10227982 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10227982 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10227982 | lld:pubmed |
