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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-5-18
pubmed:abstractText
The retinal vasculature of postmortem normal human and diabetic eyes was studied using an immunohistochemical technique in conjunction with confocal laser scanning microscopy. The technique, which stained for von Willebrand factor, allowed both large areas of the retinal vasculature to be visualised and abnormalities to be studied in detail without disturbing the tissue architecture. Only one microaneurysm, defined as any focal capillary dilation, was observed in 10 normal eyes but numerous microaneurysms were seen in 4 out of 5 diabetic retinas; counts varied between 0 and 26 per 0.41 mm2 sample area. Microaneurysms were classified into 3 categories according to morphology: saccular, fusiform and focal bulges. Most were saccular, these having no preferred orientation. The majority of microaneurysms were associated with just 2 vessels suggesting they were unlikely to develop at vascular junctions. The majority were observed to originate from the inner nuclear layer and were therefore in the deeper part of the inner retinal capillary plexus. Variation in the staining of microaneurysms may correlate with endothelial dysfunction seen clinically as dye leakage during fluorescein angiography.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-13742591, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-14189723, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-14830727, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-2064254, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-2597068, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-2696169, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-5497219, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-7556462, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-7615020, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-7742285, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-8703863, http://linkedlifedata.com/resource/pubmed/commentcorrection/10227670-8814743
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-8782
pubmed:author
pubmed:issnType
Print
pubmed:volume
194 ( Pt 1)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-100
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Three dimensional analysis of microaneurysms in the human diabetic retina.
pubmed:affiliation
Department of Ophthalmology, and School of Biological Sciences, University of Manchester, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't