Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-6-1
pubmed:abstractText
During the life cycle of the streptomycetes, large numbers of hyphae die; the surviving ones undergo cellular differentiation and appear as chains of spores in the mature colony. Here we report that the hyphae of Streptomyces antibioticus die through an orderly process of internal cell dismantling that permits the doomed hyphae to be eliminated with minimum disruption of the colony architecture. Morphological and biochemical approaches revealed progressive disorganization of the nucleoid substructure, followed by degradation of DNA and cytoplasmic constituents with transient maintenance of plasma membrane integrity. Then the hyphae collapsed and appeared empty of cellular contents but retained an apparently intact cell wall. In addition, hyphal death occurred at specific regions and times during colony development. Analysis of DNA degradation carried out by gel electrophoresis and studies on the presence of dying hyphae within the mycelium carried out by electron microscopy revealed two rounds of hyphal death: in the substrate mycelium during emergence of the aerial hyphae, and in the aerial mycelium during formation of the spores. This suggests that hyphal death in S. antibioticus is somehow included in the developmental program of the organism.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-1444261, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-1590988, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-1639187, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-1648446, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-1809356, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-2692245, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-3343216, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-347027, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-3534138, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-360964, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-3891055, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-4836123, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-5488465, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-7494469, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-7494471, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-7504906, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-7521510, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-7764707, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-7802973, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-7846528, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-7846533, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-786257, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8012610, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8124715, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8144478, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8156506, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-821930, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8491384, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8500179, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8522419, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8596463, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8637856, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8706120, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8871954, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-8885274, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-9039261, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-9347220, http://linkedlifedata.com/resource/pubmed/commentcorrection/10225953-9387219
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
515-25
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Hyphal death during colony development in Streptomyces antibioticus: morphological evidence for the existence of a process of cell deletion in a multicellular prokaryote.
pubmed:affiliation
Laboratorio de Microbiología, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't