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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-5-17
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pubmed:abstractText |
The E2F family of transcription factors plays a key role in the control of cell-cycle progression. Some family members may act as oncogenes, others as tumor-suppressor genes. The genetic changes and the expression of E2F-1 and -3 were examined in human gastric and colorectal carcinomas by Southern, Northern and Western blots. Gene amplification of E2F-1 was detected in 4% (1/23) of gastric carcinomas and 25% (3/12) of the colorectal carcinomas. Increased expression of E2F-1 mRNA was observed in 40% (12/30) of the gastric carcinomas and in 60% (3/5) of the colorectal carcinomas in comparison with the corresponding non-neoplastic mucosa. Over-expression of E2F-1 protein was confirmed in many of the gastric carcinomas. In contrast, expression levels of E2F-3 mRNA were lower in 70% (21/30) of the gastric carcinomas and in 20% (1/5) of the colorectal carcinomas than in their corresponding normal counterparts, while gross alteration of the E2F-3 gene was not detected. These results suggest that gene amplification and anomalous expression of the E2F gene may permit development of gastrointestinal carcinomas.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E2F Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/E2F1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/E2F1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/E2F3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/E2F3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma-Binding Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor DP1,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0020-7136
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
535-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10225440-Adult,
pubmed-meshheading:10225440-Aged,
pubmed-meshheading:10225440-Carrier Proteins,
pubmed-meshheading:10225440-Cell Cycle Proteins,
pubmed-meshheading:10225440-Colorectal Neoplasms,
pubmed-meshheading:10225440-DNA-Binding Proteins,
pubmed-meshheading:10225440-E2F Transcription Factors,
pubmed-meshheading:10225440-E2F1 Transcription Factor,
pubmed-meshheading:10225440-E2F3 Transcription Factor,
pubmed-meshheading:10225440-Female,
pubmed-meshheading:10225440-Gene Amplification,
pubmed-meshheading:10225440-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10225440-Humans,
pubmed-meshheading:10225440-Male,
pubmed-meshheading:10225440-Middle Aged,
pubmed-meshheading:10225440-Neoplasm Staging,
pubmed-meshheading:10225440-RNA, Messenger,
pubmed-meshheading:10225440-Retinoblastoma-Binding Protein 1,
pubmed-meshheading:10225440-Stomach Neoplasms,
pubmed-meshheading:10225440-Transcription, Genetic,
pubmed-meshheading:10225440-Transcription Factor DP1,
pubmed-meshheading:10225440-Transcription Factors
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pubmed:year |
1999
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pubmed:articleTitle |
Expression of the E2F family in human gastrointestinal carcinomas.
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pubmed:affiliation |
First Department of Pathology, Hiroshima University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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