Linked Life Data

10225140

Source:http://linkedlifedata.com/resource/pubmed/id/10225140

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-6-29
pubmed:abstractText
1. Elevated plasma lipoprotein (a) (Lp(a)) concentrations have been correlated with an increased risk of premature cardiovascular disease. The plasma Lp(a) concentration is quantitatively heritable and the apolipoprotein (Apo) A gene is known as a major locus-determining Lp(a) concentration. 2. The aim of the present study was to evaluate the genetic effect of polymorphisms in the 5'-untranslated region (UTR) of the ApoA gene on plasma concentrations of Lp(a). 3. We analysed two sequence variations in the 5'-UTR, a pentanucleotide repeat (PNR) polymorphism and haplotypes composed of three single base substitutions, in 325 Japanese subjects. The ApoA size polymorphism was also analysed by western blotting. 4. The plasma Lp(a) concentration was inversely correlated with the size of the ApoA molecule. Both PNR and the haplotype polymorphisms had significant effects on serum Lp(a) concentrations (P = 0.001 and 0.004, respectively) when the effects were evaluated by ANCOVA using the ApoA size polymorphism as a covariate. 5. When a stratified subpopulation with a larger ApoA size was analysed, both variations influenced or tended to influence the serum Lp(a) concentration, confirming the results of the ANCOVA. 6. Pentanucleotide repeat showed a tight linkage disequilibrium with the haplotypes. This disequilibrium may account for the apparent effects of PNR on Lp(a) concentrations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0305-1870
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
304-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Effects of apolipoprotein A gene polymorphisms on lipoprotein (a) concentrations in Japanese.
pubmed:affiliation
Department of Laboratory Medicine, Shimane Medical University, Izumo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't