Source:http://linkedlifedata.com/resource/pubmed/id/10223460
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1999-5-19
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pubmed:abstractText |
Symptoms from Parkinson's disease improve after surgical ablation of the medial globus pallidus (GPm). Although, in theory, selective chemical ablation of neurons in the GPm could preserve vital structures jeopardized by surgery, the potential of this approach is limited when using traditional techniques of drug delivery. The authors examined the feasibility of convection-enhanced distribution of a neurotoxin by high-flow microinfusion to ablate the neurons of the GPm selectively and reverse experimental Parkinson's disease (akinesia, tremor, and rigidity).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-3085
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
928-34
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10223460-Animals,
pubmed-meshheading:10223460-Drug Evaluation, Preclinical,
pubmed-meshheading:10223460-Feasibility Studies,
pubmed-meshheading:10223460-Globus Pallidus,
pubmed-meshheading:10223460-Ibotenic Acid,
pubmed-meshheading:10223460-Infusions, Intra-Arterial,
pubmed-meshheading:10223460-Infusions, Parenteral,
pubmed-meshheading:10223460-Kainic Acid,
pubmed-meshheading:10223460-MPTP Poisoning,
pubmed-meshheading:10223460-Macaca mulatta,
pubmed-meshheading:10223460-Parkinson Disease, Secondary,
pubmed-meshheading:10223460-Stereotaxic Techniques
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pubmed:year |
1999
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pubmed:articleTitle |
Reversal of experimental parkinsonism by using selective chemical ablation of the medial globus pallidus.
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pubmed:affiliation |
Central Nervous System Implantation Unit, Surgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
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pubmed:publicationType |
Journal Article
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