Linked Life Data

10223195

Source:http://linkedlifedata.com/resource/pubmed/id/10223195

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-5-20
pubmed:abstractText
The objective of this experiment was to compare the effects of diets with either a non-fermentable fibre source (cellulose) or a fermentable fibre source [galacto-oligosaccharide (GOS)], combined with different levels of dietary fat, on the development of colorectal cancer. Male Wistar rats were fed AIN76-based diets with either a low or high level of cellulose, or a low or high level of GOS, for 9 months. The fat content of the diets was low, medium or high. All rats were treated with 1,2-dimethylhydrazine to induce colorectal tumours. Generally, the tumour incidence increased with increasing fat content in the diet. Despite marked faeces bulking, dietary cellulose either had no effect or an enhancing effect on the formation of colorectal tumours in general, although the development of carcinomas was decreased. GOS appeared to be highly protective against the development of colorectal tumours, as was demonstrated by an inhibitory effect on tumour incidence, multiplicity and size, regardless of the fat content of the diet. Neither fibre source influenced the bromodeoxyuridine labelling index determined in colon crypts or tumours. In animals fed high-GOS diets, the caecal content was significantly increased in weight and significantly decreased in pH. It was concluded that tumorigenesis was enhanced by increased fat content of the diet, and that the diets containing fermentable GOS conferred a greater protection against colorectal cancer than did the diets containing non-fermentable cellulose.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0143-3334
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
651-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10223195-1,2-Dimethylhydrazine, pubmed-meshheading:10223195-Animals, pubmed-meshheading:10223195-Bile Acids and Salts, pubmed-meshheading:10223195-Carcinogens, pubmed-meshheading:10223195-Cecum, pubmed-meshheading:10223195-Cellulose, pubmed-meshheading:10223195-Cocarcinogenesis, pubmed-meshheading:10223195-Colorectal Neoplasms, pubmed-meshheading:10223195-Dietary Fats, pubmed-meshheading:10223195-Dietary Fiber, pubmed-meshheading:10223195-Fermentation, pubmed-meshheading:10223195-Galactose, pubmed-meshheading:10223195-Gastrointestinal Contents, pubmed-meshheading:10223195-Hydrogen-Ion Concentration, pubmed-meshheading:10223195-Male, pubmed-meshheading:10223195-Oligosaccharides, pubmed-meshheading:10223195-Plant Oils, pubmed-meshheading:10223195-Rats, pubmed-meshheading:10223195-Rats, Wistar, pubmed-meshheading:10223195-Specific Pathogen-Free Organisms
pubmed:year
1999
pubmed:articleTitle
A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat backgrounds.
pubmed:affiliation
TNO Nutrition and Food Research Institute, Department of General Toxicology, Zeist, The Netherlands. wijnands@voeding.tno.nl
pubmed:publicationType
Journal Article, Comparative Study