Source:http://linkedlifedata.com/resource/pubmed/id/10221916
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5415
|
| pubmed:dateCreated |
1999-5-20
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| pubmed:abstractText |
Infection of macaques with chimeric simian-human immunodeficiency virus (SHIV) provides an excellent in vivo model for examining the influence of envelope on HIV-1 pathogenesis. Infection with a pathogenic CCR5 (R5)-specific enveloped virus, SHIVSF162P, was compared with infection with the CXCR4 (X4)-specific SHIVSF33A.2. Despite comparable levels of viral replication, animals infected with the R5 and X4 SHIV had distinct pathogenic outcomes. SHIVSF162P caused a dramatic loss of CD4+ intestinal T cells followed by a gradual depletion in peripheral CD4+ T cells, whereas infection with SHIVSF33A.2 caused a profound loss in peripheral T cells that was not paralleled in the intestine. These results suggest a critical role of co-receptor utilization in viral pathogenesis and provide a reliable in vivo model for preclinical examination of HIV-1 vaccines and therapeutic agents in the context of the HIV-1 envelope protein.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0036-8075
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
284
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
816-9
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| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10221916-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10221916-Animals,
pubmed-meshheading:10221916-CD4 Lymphocyte Count,
pubmed-meshheading:10221916-CD4-CD8 Ratio,
pubmed-meshheading:10221916-Chimera,
pubmed-meshheading:10221916-Colon,
pubmed-meshheading:10221916-HIV-1,
pubmed-meshheading:10221916-Immunity, Mucosal,
pubmed-meshheading:10221916-Intestinal Mucosa,
pubmed-meshheading:10221916-Jejunum,
pubmed-meshheading:10221916-Macaca mulatta,
pubmed-meshheading:10221916-Reassortant Viruses,
pubmed-meshheading:10221916-Receptors, CCR5,
pubmed-meshheading:10221916-Receptors, CXCR4,
pubmed-meshheading:10221916-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10221916-Simian immunodeficiency virus,
pubmed-meshheading:10221916-Viral Load,
pubmed-meshheading:10221916-Viremia,
pubmed-meshheading:10221916-Virus Replication
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs.
|
| pubmed:affiliation |
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|