Linked Life Data

10221329

Source:http://linkedlifedata.com/resource/pubmed/id/10221329

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-7-9
pubmed:abstractText
Flow cytometric DNA-index (DI(FCM)) and karyotype were analysed in 82 consecutive children with acute lymphoblastic leukemia (ALL) during a 10 year period. A statistically significant correlation existed between modal chromosome number and DI(FCM) (p = 0.009). DI(FCM) could reliably identify leukemias with >51 chromosomes, whereas only three out of 12 cases with modal chromosome numbers between 47-51 were classified as aneuploid by DI(FCM). In the pseudodiploid group only one out of 20 leukemias had a DI(FCM) > 1.0. Five leukemias with a diploid karyotype showed an aneuploid DI(FCM) and in three patients the flow cytometric measurement revealed biclonality undetected by karyotyping. During treatment aneuploid clones could be detected by DI(FCM) in a substantial number of cases where the cytogenetic analysis was normal, and the opposite was also demonstrated in one case. DI(FCM) gave prognostic information, showing that cases with a DI > 1.12 (corresponding to 51 chromosomes) had a superior outcome with treatment protocols today in use.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0921-8912
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-56
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Flow cytometric DNA index and karyotype in childhood lymphoblastic leukemia.
pubmed:affiliation
Department of Pediatrics, Umeå University, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't