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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-5-7
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pubmed:abstractText |
The effects of two Ca2+ antagonists nifedipine (NF) and diltiazem (DL) and of the nonselective beta-adrenergic blocking agent propranolol (PR) on the hexobarbital (HB) sleeping time and on the activity of some liver drug-metabolizing enzyme systems in male Wistar rats were studied. Two h after single oral administration PR (50 mg/kg) did not change HB sleeping time, while NF (50 mg/kg) and DL (30 mg/kg) prolonged it by 171.2 and 99.6%, respectively. Coadmistration of PR with DL or with NF significantly prolonged HB sleep by 240.7 and 129%, respectively. Only NF increased aniline 4-hidroxylase (AH) activity (by 92%) and the total P-450 content (by 24%). PR and NF increased cytochrome b5 content and this effect was also observed with the combinations PR + NF (by 109%) and PR + DL (by 102%). The NADPH cytochrome P-450 reductase activity was significantly decreased by NF and DL and after their combination with PR. The ethymorphine-N-demethylase (EMND) and amidopyrine-N-demethylase (APND) activities were not changed. The effects of PR, NF and DL administrated alone or in combination on liver oxidative metabolism are considered as possible mechanisms of drug interactions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Aminopyrine N-Demethylase,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes b5,
http://linkedlifedata.com/resource/pubmed/chemical/Diltiazem,
http://linkedlifedata.com/resource/pubmed/chemical/Ethylmorphine-N-Demethylase,
http://linkedlifedata.com/resource/pubmed/chemical/Hexobarbital,
http://linkedlifedata.com/resource/pubmed/chemical/Hypnotics and Sedatives,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH-Ferrihemoprotein Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Nifedipine,
http://linkedlifedata.com/resource/pubmed/chemical/Propranolol
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0378-4274
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10221277-Adrenergic beta-Antagonists,
pubmed-meshheading:10221277-Aminopyrine N-Demethylase,
pubmed-meshheading:10221277-Animals,
pubmed-meshheading:10221277-Calcium Channel Blockers,
pubmed-meshheading:10221277-Cytochrome P-450 Enzyme System,
pubmed-meshheading:10221277-Cytochromes b5,
pubmed-meshheading:10221277-Diltiazem,
pubmed-meshheading:10221277-Ethylmorphine-N-Demethylase,
pubmed-meshheading:10221277-Hexobarbital,
pubmed-meshheading:10221277-Hypnotics and Sedatives,
pubmed-meshheading:10221277-Liver,
pubmed-meshheading:10221277-Male,
pubmed-meshheading:10221277-NADPH-Ferrihemoprotein Reductase,
pubmed-meshheading:10221277-Nifedipine,
pubmed-meshheading:10221277-Propranolol,
pubmed-meshheading:10221277-Rats,
pubmed-meshheading:10221277-Rats, Wistar,
pubmed-meshheading:10221277-Sleep
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pubmed:year |
1999
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pubmed:articleTitle |
Combined effect of propranolol with nifedipine or with diltiazem on rat liver monooxygenase activities.
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pubmed:affiliation |
Laboratory of Drug Toxicology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia. mrkoleva@iph.bio.bas.bg
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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