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rdf:type |
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lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0019564,
umls-concept:C0086982,
umls-concept:C0205087,
umls-concept:C0205390,
umls-concept:C0206249,
umls-concept:C0243067,
umls-concept:C0332161,
umls-concept:C0814087,
umls-concept:C1155589,
umls-concept:C1533691,
umls-concept:C1707520,
umls-concept:C2349975
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pubmed:issue |
9
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pubmed:dateCreated |
1999-6-10
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pubmed:abstractText |
To study the physiological and molecular mechanisms of age-related memory loss, we assessed spatial memory in C57BL/B6 mice from different age cohorts and then measured in vitro the late phase of hippocampal long-term potentiation (L-LTP). Most young mice acquired the spatial task, whereas only a minority of aged mice did. Aged mice not only made significantly more errors but also exhibited greater individual differences. Slices from the hippocampus of aged mice exhibited significantly reduced L-LTP, and this was significantly and negatively correlated with errors in memory. Because L-LTP depends on cAMP activation, we examined whether drugs that enhanced cAMP would attenuate the L-LTP and memory defects. Both dopamine D1/D5 receptor agonists, which are positively coupled to adenylyl cyclase, and a cAMP phosphodiesterase inhibitor ameliorated the physiological as well as the memory defects, consistent with the idea that a cAMP-protein kinase A-dependent signaling pathway is defective in age-related spatial memory loss.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-10456078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-10467587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-1382333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-1716012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-2085779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-221551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-2471092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-3062466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-3185855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-3401749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-4295027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-4736697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-7451838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-7472469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-7482988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-7708662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-7777673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-7781067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-7923378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8066450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8321393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8323729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8367010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8389057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8725914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8757251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8790433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8848095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8850327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8883954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-8978606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-9048751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-9054501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-9185554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-9192688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-9227840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-9230435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-9347351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-9425202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10220457-9844008
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5280-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10220457-Aging,
pubmed-meshheading:10220457-Animals,
pubmed-meshheading:10220457-Cyclic AMP,
pubmed-meshheading:10220457-Dopamine Agonists,
pubmed-meshheading:10220457-Hippocampus,
pubmed-meshheading:10220457-Long-Term Potentiation,
pubmed-meshheading:10220457-Memory,
pubmed-meshheading:10220457-Mice,
pubmed-meshheading:10220457-Mice, Inbred BALB C,
pubmed-meshheading:10220457-Signal Transduction
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pubmed:year |
1999
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pubmed:articleTitle |
Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.
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pubmed:affiliation |
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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