rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1999-6-25
|
pubmed:abstractText |
Three C46 (1-3) and three C30 (4-6) polyacetylenic alcohols with cytotoxic activity against a small panel of human solid-tumor cell lines have been isolated from the marine sponge Petrosia sp. Although compound 1 was identified as the stereoisomer of petrocortyne A, the structures of compounds 2-5 have not been previously reported and were established by spectral methods. Compound 6 was identified as the known compound petrosiacetylene D. The stereochemistry of compounds 1-5 was determined by the modified Mosher's method.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0163-3864
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
62
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
554-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10217707-Acetylene,
pubmed-meshheading:10217707-Animals,
pubmed-meshheading:10217707-Antineoplastic Agents,
pubmed-meshheading:10217707-Artemia,
pubmed-meshheading:10217707-Chromatography, High Pressure Liquid,
pubmed-meshheading:10217707-Drug Screening Assays, Antitumor,
pubmed-meshheading:10217707-Humans,
pubmed-meshheading:10217707-Lethal Dose 50,
pubmed-meshheading:10217707-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10217707-Mass Spectrometry,
pubmed-meshheading:10217707-Polyacetylenes,
pubmed-meshheading:10217707-Polymers,
pubmed-meshheading:10217707-Porifera,
pubmed-meshheading:10217707-Spectrophotometry, Ultraviolet,
pubmed-meshheading:10217707-Tumor Cells, Cultured
|
pubmed:year |
1999
|
pubmed:articleTitle |
Cytotoxic polyacetylenes from the marine sponge Petrosia sp.
|
pubmed:affiliation |
Research Institute of Drug Development, College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|