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pubmed-article:10217588pubmed:abstractTextWe conducted a randomized, double-blind trial to evaluate the safety and tolerability of a live attenuated cold adapted trivalent intranasal influenza vaccine, FluMist, compared with intranasal placebo when given in addition to a licensed trivalent injected inactivated influenza vaccine (TIV). The study population consisted of persons 65 years of age and older with chronic cardiovascular or pulmonary conditions or diabetes mellitus. During the 7 days post-vaccination, sore throat was reported on at least one day by 15% (15/100) of FluMist recipients compared with 2% (2/100) of intranasal placebo recipients (p = 0.001). No other reactogenicity symptom was statistically associated with receipt of FluMist. Among this group, FluMist was safe and well tolerated when administered with TIV.lld:pubmed
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pubmed-article:10217588pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:10217588pubmed:articleTitleSafety of a trivalent live attenuated intranasal influenza vaccine, FluMist, administered in addition to parenteral trivalent inactivated influenza vaccine to seniors with chronic medical conditions.lld:pubmed
pubmed-article:10217588pubmed:affiliationImmunization Studies Program, Center for Health Studies, Group Health Cooperative of Puget Sound, WA, USA. lajack@u.washington.edulld:pubmed
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