Source:http://linkedlifedata.com/resource/pubmed/id/10217554
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-7-1
|
| pubmed:abstractText |
Long-term effects of drug type and other drug use related risk factors on CD4+ cell decline were assessed in 224 HIV-infected injecting drug users (IDUs) from Baltimore (ALIVE), USA, and 63 IDUs from Amsterdam, The Netherlands. Higher frequencies of borrowing used injection equipment since 1980 resulted in a higher CD4+ count already present before seroconversion (P = 0.049). Use of mainly heroin in the seroconversion interval resulted in a sharper CD4+ decline until the first 6 months after seroconversion (P = 0.004), but CD4+ values converged later on. This finding might reconcile earlier discordant epidemiological and laboratory study results regarding the possible effects of heroin.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0376-8716
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
54
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
145-54
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10217554-Adult,
pubmed-meshheading:10217554-Baltimore,
pubmed-meshheading:10217554-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10217554-Cocaine,
pubmed-meshheading:10217554-Cohort Studies,
pubmed-meshheading:10217554-Comorbidity,
pubmed-meshheading:10217554-Confounding Factors (Epidemiology),
pubmed-meshheading:10217554-Disease Progression,
pubmed-meshheading:10217554-Female,
pubmed-meshheading:10217554-HIV Infections,
pubmed-meshheading:10217554-Heroin,
pubmed-meshheading:10217554-Humans,
pubmed-meshheading:10217554-Immunocompetence,
pubmed-meshheading:10217554-Linear Models,
pubmed-meshheading:10217554-Lymphocyte Count,
pubmed-meshheading:10217554-Male,
pubmed-meshheading:10217554-Netherlands,
pubmed-meshheading:10217554-Risk Factors,
pubmed-meshheading:10217554-Substance Abuse, Intravenous
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
New evidence to reconcile in vitro and epidemiologic data on the possible role of heroin on CD4+ decline among HIV-infected injecting drug users.
|
| pubmed:affiliation |
Division of Public Health and Environment, Municipal Health Service, Amsterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|