Linked Life Data

10213676

Source:http://linkedlifedata.com/resource/pubmed/id/10213676

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-6-15
pubmed:abstractText
Reovirus type 2 (Reo-2)-infected DBA/1 suckling mice develop insulitis, resulting in a diabetes-like syndrome. In this study, the role of interleukin-2 (IL-2) in the death (destruction) of pancreatic islet cells was examined. The endogenous IL-2 activity of splenic cells in infected mice was greater than that in uninfected mice. Treatment of infected mice with monoclonal antibody against IL-2 prevented the development of insulitis with impaired glucose tolerance, in a dose-dependent manner. These results suggest that IL-2 may participate in pancreatic islet-cell destruction in Reo-2-induced diabetes-like syndrome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9975
pubmed:author
pubmed:copyrightInfo
Copyright 1999 W.B. Saunders Company Ltd.
pubmed:issnType
Print
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
313-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Role of interleukin-2 in pancreatic islet-cell destruction in reovirus type 2-infected DBA/1 suckling mice.
pubmed:affiliation
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yoshida, Yamaguchi, 753-8515, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't