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rdf:type |
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lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0011928,
umls-concept:C0026809,
umls-concept:C0069542,
umls-concept:C0079323,
umls-concept:C0185023,
umls-concept:C0237497,
umls-concept:C0301630,
umls-concept:C0521390,
umls-concept:C1314972,
umls-concept:C1533691,
umls-concept:C1947904,
umls-concept:C1999228,
umls-concept:C2348243,
umls-concept:C2825781
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pubmed:issue |
2-3
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pubmed:dateCreated |
1999-6-10
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pubmed:abstractText |
Attachments of cultured dorsal root ganglion (DRG) neurons to the extracellular matrix (ECM) proteins (type I and IV collagens, laminin and fibronectin) and the adhesion ligand arginine-glycine-aspartic acid (RGD) were impaired in mice 2 weeks after the induction of diabetes by streptozotocin (STZ). However, administration of the aldose reductase inhibitor, ONO-2235, to the STZ-diabetic mice for 1 week restored DRG neuronal attachment to the ECM proteins and RGD to a level close to normal mice. These results suggest that activation of the aldose reductase and subsequent metabolic disorders in diabetic animals may play an important role in detrimental alterations of the neuronal cell-surface receptors for the ECM proteins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldehyde Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/ONO 2235,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Rhodanine,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidines,
http://linkedlifedata.com/resource/pubmed/chemical/arginyl-glycyl-aspartic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
263
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10213159-Aldehyde Reductase,
pubmed-meshheading:10213159-Amino Acid Sequence,
pubmed-meshheading:10213159-Animals,
pubmed-meshheading:10213159-Cell Adhesion,
pubmed-meshheading:10213159-Cells, Cultured,
pubmed-meshheading:10213159-Collagen,
pubmed-meshheading:10213159-Diabetes Mellitus, Experimental,
pubmed-meshheading:10213159-Enzyme Inhibitors,
pubmed-meshheading:10213159-Extracellular Matrix Proteins,
pubmed-meshheading:10213159-Female,
pubmed-meshheading:10213159-Fibronectins,
pubmed-meshheading:10213159-Ganglia, Spinal,
pubmed-meshheading:10213159-Laminin,
pubmed-meshheading:10213159-Mice,
pubmed-meshheading:10213159-Mice, Inbred C57BL,
pubmed-meshheading:10213159-Neurons,
pubmed-meshheading:10213159-Oligopeptides,
pubmed-meshheading:10213159-Reference Values,
pubmed-meshheading:10213159-Rhodanine,
pubmed-meshheading:10213159-Thiazolidines
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pubmed:year |
1999
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pubmed:articleTitle |
Administration of an aldose reductase inhibitor, ONO-2235, to streptozotocin-diabetic mice restores reductions of DRG neuronal attachment to extracellular matrix proteins in vitro.
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pubmed:affiliation |
Division of Geriatric Health and Nutrition, National Institute of Health and Nutrition, Tokyo, Japan. kazsango@nih.go.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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