10211866

Source:http://linkedlifedata.com/resource/pubmed/id/10211866

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0009491, umls-concept:C0025663, umls-concept:C0040223, umls-concept:C0681842, umls-concept:C0683150, umls-concept:C1579762, umls-concept:C1947916
pubmed:issue	3
pubmed:dateCreated	1999-5-26
pubmed:abstractText	The objective of this study is to compare the empirical allometric approaches with species invariant time methods using equivalent time, kallynochron, apolysichron, and dienetichrons. Pharmacokinetic parameters (clearance, volume of distribution, and elimination half-life) of ethosuximide, cyclosporine and ciprofloxacin were scaled-up from animal data obtained from the literature. Two methods were utilized to generate plots for the prediction of clearance in humans: (i) clearance versus body weight (simple allometric equation); and (ii) the product of clearance and maximum life-span potential (MLP) versus body weight. Plasma concentrations of each of the drugs were predicted using elementary and complex Dedrick plots, equivalent time with an exponent of 0.25 and equivalent time with the exponent obtained from the plot of body weight and half-life. Plasma concentrations of cyclosporine and ciprofloxacin were also predicted by MLP normalization (dienetichrons). Almost similar results in the pharmacokinetic parameters of the tested drugs were obtained by the allometric approach and by the species invariant time methods.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7911226
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0142-2782
pubmed:author	pubmed-author:MahmoodII, pubmed-author:YuanRR
pubmed:issnType	Print
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	137-44
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:10211866-Animals, pubmed-meshheading:10211866-Body Weight, pubmed-meshheading:10211866-Half-Life, pubmed-meshheading:10211866-Humans, pubmed-meshheading:10211866-Metabolic Clearance Rate, pubmed-meshheading:10211866-Models, Biological, pubmed-meshheading:10211866-Pharmacokinetics
pubmed:year	1999
pubmed:articleTitle	A comparative study of allometric scaling with plasma concentrations predicted by species-invariant time methods.
pubmed:affiliation	Office of Clinical Pharmacology and Biopharmaceutics, Division of Pharmaceutical Evaluation I (HFD-860), Food & Drug Administration, Rockville, MD 20852, USA. Mahmoodi@CDER.FDA.GOV
pubmed:publicationType	Journal Article, Comparative Study