Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-4-27
pubmed:abstractText
We studied 90 adults undergoing surgical removal of at least both lower third molar teeth as day cases under standardized general anaesthesia. Patients were allocated randomly (with stratification for surgeon) to receive tenoxicam 40 mg, tenoxicam 20 mg or placebo i.v. at induction of anaesthesia and orally (effervescent tablets) with food on each of the subsequent 2 days. Panadeine (paracetamol 500 mg-codeine 8 mg) was given before operation and was available as needed for pain thereafter, to a limit of two tablets every 4 h. Nefopam i.v. was also available. Efficacy variables and adverse reactions were assessed over 6 days. Over the 6-day period, patients who received tenoxicam reported less pain on rest (area under the curve; P < 0.05) and less disturbance in sleep (P < 0.01) even though they used fewer Panadeine tablets (P < 0.05). Differences between tenoxicam 40 mg and 20 mg were not significant. There was no significant difference in nefopam requirements or side effects, and no adverse event attributable to the study medication.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0007-0912
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
875-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10211012-Acetaminophen, pubmed-meshheading:10211012-Adolescent, pubmed-meshheading:10211012-Adult, pubmed-meshheading:10211012-Analgesia, pubmed-meshheading:10211012-Analgesics, pubmed-meshheading:10211012-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:10211012-Codeine, pubmed-meshheading:10211012-Cyclooxygenase Inhibitors, pubmed-meshheading:10211012-Dose-Response Relationship, Drug, pubmed-meshheading:10211012-Double-Blind Method, pubmed-meshheading:10211012-Drug Therapy, Combination, pubmed-meshheading:10211012-Female, pubmed-meshheading:10211012-Humans, pubmed-meshheading:10211012-Male, pubmed-meshheading:10211012-Molar, Third, pubmed-meshheading:10211012-Pain, Postoperative, pubmed-meshheading:10211012-Piroxicam, pubmed-meshheading:10211012-Prospective Studies, pubmed-meshheading:10211012-Tooth Extraction
pubmed:year
1998
pubmed:articleTitle
Tenoxicam and paracetamol-codeine combination after oral surgery: a prospective, randomized, double-blind, placebo-controlled study.
pubmed:affiliation
St Marks Clinic, Auckland, New Zealand.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't