Linked Life Data

10206667

Source:http://linkedlifedata.com/resource/pubmed/id/10206667

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-4-13
pubmed:abstractText
The granulocytic antigens NA1 and NA2 are two allelic gene products of the FcgammaRIIIB gene. These antigens are frequently targets of granulocytic-specific allo-antibodies and auto-antibodies that cause neutropenias. Different distributions of these antigens have been found in population studies. In our study, the genomic DNA of 345 healthy, unrelated Spanish individuals was typed for NA1 and NA2 using polymerase chain reaction (PCR) with sequence-specific primers (SSP). The gene frequencies found in the Spanish population were 0.29 for NA1 and 0.71 fo NA2. Flow cytometry immunotyping was also carried out in 20 of these samples, and an exact correlation was observed among the results. The gene frequencies determined in our study are similar to those reported in other Caucasian populations. The null phenotype reported in other serological studies was not found. This typing system can be used in population studies instead of serological tests as a more rapid, simple and reproducible method.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0960-7420
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
393-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Determination of NA gene frequencies in the Spanish population by polymerase chain reaction with sequence-specific primers.
pubmed:affiliation
Immunology Section, Univerity Hospital Virgen de la Arrixaca, Murcia, Spain.
pubmed:publicationType
Journal Article, Comparative Study