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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11-12
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pubmed:dateCreated |
1999-5-6
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pubmed:abstractText |
Little is known about the relative contributions of genetic and environmental factors to the development of gastric cancer. Mutations in the cell adhesion molecule E-cadherin are recognized to be associated with the development of undifferentiated, diffuse and invasive gastric cancers. A recent study of two gastric cancer families has shown that germline mutations in the E-cadherin gene can be causative (Guilford P et al, Nature 1998; 26: 402-405). We have examined the E-cadherin gene for constitutive mutations in a systematic series of 106 gastric cancer patients, 10 with a family history of the disease and 96 sporadic cases. No pathogenic mutations were observed in any of the 106 patients. The results indicate that germline mutations in E-cadherin will not account for more than 3% of gastric cancers.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-14320675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-1606546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-2224804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-3387895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-3533579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-360367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-8033105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-8075649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-8127895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-8557030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-8608551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-8792301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-8797891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-9045944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-9274521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10206317-9537325
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1935-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10206317-Adenocarcinoma,
pubmed-meshheading:10206317-Cadherins,
pubmed-meshheading:10206317-Environmental Health,
pubmed-meshheading:10206317-Female,
pubmed-meshheading:10206317-Germ-Line Mutation,
pubmed-meshheading:10206317-Humans,
pubmed-meshheading:10206317-Male,
pubmed-meshheading:10206317-Middle Aged,
pubmed-meshheading:10206317-Polymorphism, Genetic,
pubmed-meshheading:10206317-Stomach Neoplasms
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pubmed:year |
1999
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pubmed:articleTitle |
Low frequency of germline E-cadherin mutations in familial and nonfamilial gastric cancer.
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pubmed:affiliation |
Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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