Linked Life Data

10203309

Source:http://linkedlifedata.com/resource/pubmed/id/10203309

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-6-3
pubmed:abstractText
Following nerve injury, modified somatic ion channels may underlie ectopic activity in axotomized A-type neurones in dorsal root ganglia (DRGs) leading to abnormal pain signalling. Using intracellular microelectrodes both in vivo and in vitro, action potentials (APs) were recorded in rat DRG neurones classified by axonal conduction velocity. After lesions to L5 spinal or sciatic nerves, APs in both A alpha/beta and A delta cells were wider, and those in A alpha/beta neurones more frequently showed inflections during repolarization, than APs in cells in undamaged ganglia. AP amplitudes and dV/dt(max) were not significantly altered by axotomy. These results confirm previous observations in intact ganglia in vitro but differ from those reported for dissociated neurones using patch recording techniques.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
201-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Changes in the action potential in sensory neurones after peripheral axotomy in vivo.
pubmed:affiliation
Prince of Wales Medical Research Institute (affiliated with the University of New South Wales), Randwick, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't