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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-7-2
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pubmed:abstractText |
Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3940
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pubmed:author |
pubmed-author:AmouyelPP,
pubmed-author:CartySS,
pubmed-author:ChakravertySS,
pubmed-author:Chartier-HarlinM CMC,
pubmed-author:CotterNN,
pubmed-author:CrookRR,
pubmed-author:FrigardBB,
pubmed-author:GoateAA,
pubmed-author:HardyJJ,
pubmed-author:HolmansPP,
pubmed-author:KehoePP,
pubmed-author:LambertJ CJC,
pubmed-author:LovestoneSS,
pubmed-author:MorrisJ CJC,
pubmed-author:NIWACC,
pubmed-author:Pérez-TurJJ,
pubmed-author:PetersenR CRC,
pubmed-author:RichCC,
pubmed-author:RudrasinghamVV,
pubmed-author:TunstallNN,
pubmed-author:Wavrant-DeVrièzeFF,
pubmed-author:WilliamsJJ,
pubmed-author:WuWW
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
262
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10203250-Age of Onset,
pubmed-meshheading:10203250-Alleles,
pubmed-meshheading:10203250-Alzheimer Disease,
pubmed-meshheading:10203250-Apolipoproteins E,
pubmed-meshheading:10203250-Case-Control Studies,
pubmed-meshheading:10203250-Gene Frequency,
pubmed-meshheading:10203250-Genetic Linkage,
pubmed-meshheading:10203250-Genotype,
pubmed-meshheading:10203250-Humans,
pubmed-meshheading:10203250-Lod Score,
pubmed-meshheading:10203250-Middle Aged,
pubmed-meshheading:10203250-Nuclear Family,
pubmed-meshheading:10203250-Polymorphism, Genetic,
pubmed-meshheading:10203250-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:10203250-alpha-Macroglobulins
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pubmed:year |
1999
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pubmed:articleTitle |
No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease.
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pubmed:affiliation |
Mayo Clinic Jacksonville, FL 32084, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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