rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1999-4-29
|
pubmed:abstractText |
Cytotoxic T lymphocytes and natural killer cells are essential effectors of anti-tumor immune responses in vivo. Dendritic cells (DC) 'prime' tumor antigen-specific cytotoxic T lymphocytes; thus, we investigated whether DC might also trigger the innate, NK cell-mediated anti-tumor immunity. In mice with MHC class I-negative tumors, adoptively transferred- or Flt3 ligand-expanded DC promoted NK cell-dependent anti-tumor effects. In vitro studies demonstrated a cell-to-cell contact between DC and resting NK cells that resulted in a substantial increase in both NK cell cytolytic activity and IFN-gamma production. Thus, DC are involved in the interaction between innate and adaptive immune responses.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
1078-8956
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
5
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
405-11
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10202929-Adoptive Transfer,
pubmed-meshheading:10202929-Animals,
pubmed-meshheading:10202929-Cell Communication,
pubmed-meshheading:10202929-Coculture Techniques,
pubmed-meshheading:10202929-Cytotoxicity, Immunologic,
pubmed-meshheading:10202929-DNA-Binding Proteins,
pubmed-meshheading:10202929-Dendritic Cells,
pubmed-meshheading:10202929-Killer Cells, Natural,
pubmed-meshheading:10202929-Ligands,
pubmed-meshheading:10202929-Lymphocyte Activation,
pubmed-meshheading:10202929-Major Histocompatibility Complex,
pubmed-meshheading:10202929-Membrane Proteins,
pubmed-meshheading:10202929-Mice,
pubmed-meshheading:10202929-Mice, Inbred Strains,
pubmed-meshheading:10202929-Mice, Mutant Strains,
pubmed-meshheading:10202929-Neoplasms, Experimental
|
pubmed:year |
1999
|
pubmed:articleTitle |
Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.
|
pubmed:affiliation |
Département de Biologie Clinique, Institut Gustave Roussy, Villejuif, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|