Linked Life Data

10202688

Source:http://linkedlifedata.com/resource/pubmed/id/10202688

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-5-17
pubmed:abstractText
Kasugamycin, a unique aminoglycoside antibiotic, has been used for many years solely for crop protections. In general, aminoglycoside antibiotics possess broad and strong inhibitory activity against both Gram-positive and -negative bacteria, however, kasugamycin merely exhibits limited activity against phytopathogenic microbes such as Pyricularia oryzae and certain strains of pseudomonads. Recently, in human and animal chemotherapy, it has been seriously concerned about the emergence of multiply resistant bacteria by consumption of a large amount of antibiotics not only for therapy but also for growth-promotion of farm animals. It was believed that kasugamycin, the agricultural antibiotic, does not undergo any cross-resistance with other clinically important aminoglycoside antibiotics because of its weak or almost no activity against common pathogenic microbes except for some phytopathogenic fungi and pseudomonads. However, no confirmative study on this fact has been published so far. In this study, we compared activity of kasugamycin with those of twelve clinically used aminoglycoside antibiotics against susceptible standard strains and well-characterized aminoglycoside-resistant strains as well as clinically isolated strains, in order to show the least potential of kasugamycin to create cross-resistant human pathogens against clinically important aminoglycoside antibiotics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0368-2781
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-67
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Comparative studies on in vitro activities of kasugamycin and clinically-used aminoglycoside antibiotics.
pubmed:affiliation
Central Research Laboratories, Hokko Chemical Industry Co., Ltd., Kanagawa, Japan.
pubmed:publicationType
Journal Article, Comparative Study